Which active ingredients can be included in combinations with narcotics for Schedule IV?

The correct answer is non-narcotic ingredients. In South Dakota, as well as in federal regulations, Schedule IV controlled substances can include combinations of narcotics with non-narcotic active ingredients. This is particularly relevant for formulations such as cough syrups or pain medications, where non-narcotic ingredients can enhance efficacy or modify the drug's action without increasing the potential for abuse.

Using only narcotic ingredients in combinations would not align with the intended regulatory framework, which aims to manage and control substances based on their potential for abuse and dependence. Therefore, the inclusion of non-narcotic active ingredients provides a safe way to formulate medications that may still offer therapeutic benefits while mitigating the risk of addiction.

Vitamin and mineral supplements do not qualify as active ingredients in the context of drug manufacturing and pharmaceutical regulation. They do not have the therapeutic effects commonly associated with active pharmaceutical ingredients, particularly in relation to the conditions for which controlled substances are prescribed.