Which of the following is a criterion for drugs in Schedule II?

Drugs classified in Schedule II are identified by their high potential for abuse, which can lead not only to severe psychological or physical dependence but also to significant risk of addiction or misuse. This classification reflects the recognition that, while these substances have accepted medical uses, their potential to be abused is greater than that of drugs in Schedules III through V.

The correct answer highlights that Schedule II drugs are those that carry a higher potential for abuse, resulting in severe dependence. This characteristic is essential in regulating their distribution and use within healthcare settings, ensuring that prescribing practices are closely monitored to safeguard against misuse.

The alternate choices either mischaracterize the medical use of Schedule II drugs or describe lower schedules that pertain to substances with less stringent abuse potential. For instance, a classification of drugs with no accepted medical use belongs to Schedule I, while accepted medical use without restrictions typically refers to drugs in Schedules III, IV, or V, which do not carry the same level of concern regarding abuse and dependence.